Considering that it is impossible to fight women’s vulnerability to HIV without an active process of empowering women, we began a South-South Project in partnership with organizations from different social sectors in Latin America, the Caribbean, Asia, Africa and Eastern Europe, to identify gaps and progress in implementing actions of sexual and reproductive rights of women and girls to face the HIV/AIDS epidemic. The activities include capacity building and the creation of strategies to mobilize the community for actions of promotion, research surveys and monitoring actions.